> For the complete documentation index, see [llms.txt](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/vci-help/evaluating-criteria/case-segregation-data.md).

# Case/Segregation Data

SOP Section 9.5

#### Case/Segregation Tab Organization

{% hint style="danger" %}
Do NOT enter protected health information (PHI) in the VCI

(See yellow box at top of VCI Case/Segregation Tab)
{% endhint %}

A. If no curated evidence has been associated with this variant, the ACMG criteria codes for evaluation immediately follow the yellow box. Curated Evidence may be associated with the following individual and pairs of criteria (from top to bottom): <mark style="color:purple;">**BS2**</mark>, <mark style="color:red;">**PS4**</mark>, <mark style="color:purple;">**BS4**</mark>**/**<mark style="color:green;">**PP1**</mark>, <mark style="color:orange;">**PM6**</mark>**/**<mark style="color:red;">**PS2**</mark>, <mark style="color:blue;">**BP2**</mark>**/**<mark style="color:orange;">**PM3**</mark>, <mark style="color:blue;">**BP5**</mark>, and <mark style="color:green;">**PP4**</mark>.

B. If curated evidence has been added (to the current interpretation or a prior one), a table summarizing all entered evidence will appear before the criteria codes. This table will auto populate with any new submitted evidence.

<div align="left"><img src="https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FBdzN5xdUva9L7acOtOp6%2Fc%3As%20tab%20top.png?alt=media&amp;token=5def941d-09a3-488e-8ff7-1e84759602b0" alt="A. No prior Curated Evidence"> <img src="https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FFd1fBdZYUBZtJ1VrwEIC%2Fc%3As%20tab%20top%20with%20table.png?alt=media&amp;token=bc6e74ec-6fc8-4e5e-a64a-f3213a5af3fd" alt="B. Curated Evidence previously added"></div>

#### Adding Curated Evidence&#x20;

Scroll down or select a criterion from the Criteria Bar.

Evaluation of criteria may be completed before or after adding Curated Evidence.

![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FxAggeAegmRtq0jpwR26j%2Fc%3As%20pp4.png?alt=media\&token=eb7f2640-bba2-4549-ae14-2da600e6ecf1)

Before adding evidence, you must select an evidence source.

<img src="https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FGweU61OYBORLKsJ6TGn9%2Fadd%20evidence%20no.png?alt=media&amp;token=3e564acb-d117-437e-9113-8f3e8499c18e" alt="" data-size="original">![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FuIrJoYXooIRZCbT2GIFt%2Fadd%20evidence%20yes.png?alt=media\&token=1d91e266-5655-47b2-ae79-d25515065b32)

Choose an option from the "Select Source" pulldown

![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2F8kIrwfilTvUV9zH8GLxA%2Fc%3As%20pp4%20pulldown.png?alt=media\&token=6d08e8da-a75a-48f1-8536-5919c6ee8fa3)

Click <img src="https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2Fjf4REPnsJq90LP3VF49l%2Fadd%20evidence%20button.png?alt=media&amp;token=306cbfd9-1810-41ce-a2be-5a41f07dc2ba" alt="" data-size="line"> to open the **Add \[Source] Evidence** selection screen.&#x20;

Available fields vary based on the source:

![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2F1OzTFI8yDE7UZLIbCVjL%2Fadd%20clinic%20modal.png?alt=media\&token=299f033f-8ce0-48fe-84c8-122d2fcb5b28) ![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2F7jNZrvMGEOl7TsNoQAPi%2Fadd%20database%20modal.png?alt=media\&token=ae00514c-5595-445d-8719-063963b9d828) ![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FsYYVOTrGltPiGbcNLPPR%2Fadd%20clin%20lab%20modal.png?alt=media\&token=d2acf27a-7859-4798-8b0e-f521d2ec8291) ![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FDTTZThQr5akGlIVYCT0P%2Fadd%20research%20lab%20modal.png?alt=media\&token=27b408ef-b493-437f-b4ab-89ccd12cc461)

![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FJDpouajfNaDk3UAOaoil%2Fother%20and%20pmid%20modals.png?alt=media\&token=dbba40d5-0713-490e-b4fc-10201569c8f2)

The first field is required (indicated with **\***). Additional fields are optional.

![](https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2FXtgKZWwnFECvXQ7FUrgo%2Fadd%20evidence%20req%20field.png?alt=media\&token=b5cc0474-55ec-497c-a309-5e4b0f43453f)&#x20;

After filling in field(s), click <img src="https://453646021-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FzjRMfxI6chghHwy4VhQv%2Fuploads%2F7jZMjZRWA0wHOwqBCeHS%2Fnext%20button.png?alt=media&amp;token=c5a40da9-e0ba-409c-bc1f-7c509b350b2f" alt="" data-size="line"> to open the **Add Evidence Details** selection screen.


---

# Agent Instructions
This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com.

## Querying This Documentation
If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter, and the optional `goal` query parameter:

```
GET https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/vci-help/evaluating-criteria/case-segregation-data.md?ask=<question>&goal=<endgoal>
```

`ask` is the immediate question: it should be specific, self-contained, and written in natural language.
`goal` is optional and describes the broader end goal you are ultimately trying to accomplish on behalf of the user. GitBook uses it to tailor the answer towards what is most useful for that goal.

The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.
