> For the complete documentation index, see [llms.txt](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/more-information/about-us.md). # About Us #### Clinical Genome Resource (ClinGen) The National Human Genome Research Institute (NHGRI) established the [Clinical Genome (ClinGen) Resource](https://clinicalgenome.org/) Consortium in 2013 to fill a gap of organized, available information about which genes and genomic variants are relevant to human disease. The Consortium works to identify which genes are associated with disease (through a process known as gene curation) and which variants in those genes are disease-causing (via variant curation). Then, they work to standardize the way researchers document and share information about those variants. #### Stanford ClinGen The primary work of the Stanford ClinGen team focuses on the development of software infrastructure to support the gene-disease curation and variant curation processes that provide the curated information to build ClinGen’s publicly available knowledgebase. Two such pieces of essential software include: the Variant Curation Interface (VCI), which supports the FDA-recognized ClinGen [variant pathogenicity curation](https://clinicalgenome.org/curation-activities/variant-pathogenicity/) process, and the Gene Curation Interface (GCI), which supports gene-disease curation following ClinGen’s [gene-disease clinical validity curation](https://www.clinicalgenome.org/curation-activities/gene-disease-validity/) framework. The VCI and GCI enable curators to associate pertinent evidence with variant interpretations and gene-disease associations, to assess evidence per variant and gene curation protocols, to support expert review of the curated data, and to make their assertions publicly available so that they can be used by anyone seeking to improve patient care through genomic medicine. The VCI is a community curation tool, and so all interested variant curators are encouraged to [sign up](https://curation.clinicalgenome.org/) to use it. --- # Agent Instructions This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com. ## Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter, and the optional `goal` query parameter: ``` GET https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/more-information/about-us.md?ask=&goal= ``` `ask` is the immediate question: it should be specific, self-contained, and written in natural language. `goal` is optional and describes the broader end goal you are ultimately trying to accomplish on behalf of the user. GitBook uses it to tailor the answer towards what is most useful for that goal. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.