Evaluating Criteria
Criteria placement & organization
The ACMG criteria are grouped in the VCI according to the evidence required for their evaluation. To evaluate them curators must navigate to the appropriate tab:
BA1
BS1
PM2
Each of the VCI tabs with criteria codes also supports users in manually adding Curated Evidence.
The Basic Information and Gene-centric tabs are for reference only. They do not contain criteria requiring evaluation or fields to add curated evidence.
Criteria evaluation options
The pull-downs allow the following choices:
Not Evaluated: The default state of an Evaluation is “Not Evaluated”. This is the appropriate selection when there is no evidence to evaluate or the particular criterion is not applicable for the variant.
Met: If the evidence meets the specified rules for a given criterion, the curator should select “Met”. Curators should provide an explanation note for all Met criteria.
Not Met: Not met can be applied if:
No evidence is identified for the criterion, OR
There is evidence, but it is not sufficient, OR
Another mutually exclusive criterion has been met.
Curators should provide an explanation note for all Not Met criteria.
Strength: The strength of evaluation for a criterion can be adjusted by selecting a strength from the pull down menu for a specific criterion.
Steps for evaluating a criterion or criteria:
Examine evidence associated with criteria being evaluated
Select an evaluation for all criteria related to the evidence from the pull-down
Enter an explanation in the free text box to support your selection
Click Save
Correct the erroneous evaluation and then save to proceed.
Curation Checkboxes
At the bottom of each tab which includes criteria for evaluation, you will see the following checkbox:
If you have evaluated all of the evidence on a particular tab to your satisfaction, you can click the checkbox and a check will appear on the tab for your reference:
This is an optional tool available to help track your progress. It is not required and is not included in the evaluation summary.
Criteria Bar
As you save your evaluations, you will notice that the Criteria Bar will indicate which criteria have been “Met” (solid color background with white criteria code), “Not Met” (grey background with colored criteria code), or remain “Not Evaluated” (white background with colored criteria code).
Additionally, the Progress Bar will automatically calculate the pathogenicity each time you save or update an evaluation
Auto-calculated Classification
The calculated classifications follow the ACMG/AMP 5 tiers and are as follows:
Benign
Likely benign
Uncertain significance
Pathogenic
Likely pathogenic
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