About Variant Curation
The ClinGen variant curation process combines clinical, genetic, population, and functional evidence with expert review to classify variants into one of five categories according to the ACMG guidelines. Approved variant interpretations are published to the ClinGen Evidence Repository (ERepo) and to ClinVar.
The Variant Curation Interface (VCI) supports community curation and is available to any interested curator. For information on how to register, see Account Creation and Login.
The VCI supports the ClinGen FDA-recognized curation workflow, summarized in the diagram below:

For more information about ClinGen variant curation, please contact the Variant Curation Working Group at variantcuration@clinicalgenome.org.
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