# About Variant Curation

The ClinGen variant curation process combines clinical, genetic, population, and functional evidence with expert review to classify variants into one of five categories according to the [ACMG guidelines](https://www.acmg.net/docs/standards_guidelines_for_the_interpretation_of_sequence_variants.pdf)**.** Approved variant interpretations are published to the [ClinGen Evidence Repository (ERepo)](https://erepo.clinicalgenome.org/evrepo/) and to [ClinVar](https://www.ncbi.nlm.nih.gov/clinvar/). 

The Variant Curation Interface (VCI) supports community curation and is available to any interested curator. For information on how to register, see [Account Creation and Login](/vci-gci-docs/getting-started-in-the-vci-and-gci/account-creation-and-login.md).

The VCI supports the ClinGen FDA-recognized curation workflow, summarized in the diagram below:

![](/files/x7PRxLvT4l7I8dAI3jH8)

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The ClinGen General Sequence Variant Curation Process Standard Operating Procedure [(SOP)](https://www.clinicalgenome.org/docs/variant-curation-standard-operating-procedure-version-3/) provides guidance on variant classification using ClinGen approved processes and tools. The SOP is updated periodically; updates will be announced during ClinGen curator calls and via mailing lists. Additional variant curation training materials are available [here](https://www.clinicalgenome.org/curation-activities/variant-pathogenicity/training-materials/).
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For more information about ClinGen variant curation, please contact the Variant Curation Working Group at <variantcuration@clinicalgenome.org>.


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