> For the complete documentation index, see [llms.txt](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/gci-help/evidence-collection-experimental-evidence/rescue-evidence.md).
# Rescue Evidence
Rescue evidence shows that the phenotype in humans (i.e. patients with the condition), non-human model organisms, cell culture models, or patient cells can be rescued.
Curation of rescue evidence is based on whether rescue of the phenotype was observed in a **human**, a **non-human model organism**, a **cell culture model** or **patient cells**; select the appropriate option from the pull-down menu:
The curation interface for all options has a number of required fields, shown with an asterisk next to the field. The required fields are:
* **Experiment name** is a free-text field; please choose a descriptive name for the experiment.
* **Description of gene alteration** is a free-text field that enables you to describe how the endogenous gene was altered in the experiment.
* **Phenotype to rescue** requires an entry in the Human Phenotype Ontology (HPO) ID or the free text field.
* **Description of method used to rescue** is a free-text field.
For the "**Non-human model organism**" option, the additional required field is:
* **Non-human model organism** presents a dropdown menu of non-human model organism options. New organisms can be added upon request; please email us at .
For the "**Cell culture model**" option, the additional required field is:
* **Cell culture model type/line** requires an entry in either the Experimental Factor Ontology (EFO)/Cell Ontology (CL) ID or the free text field.
For the "**Patient cells**" option, the additional required field is:
* **Patient cell type/line** requires an entry in the Cell Ontology (CL) ID or the free text field.
Links to the Human Phenotype Ontology (HPO), Cell Ontology (CL) and the Experimental Factor Ontology (EFO) are provided to aid in searching for the correct ID.
Finally, select whether the experimental evidence should be scored, brought up for review by the GCEP, or contradicts the gene-disease association.
{% hint style="warning" %}
Remember to click the "Save" button at the bottom of the page. If you click "Cancel" or navigate away from the page without saving, all entered data will be lost.
{% endhint %}
---
# Agent Instructions
This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com.
## Querying This Documentation
If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.
Perform an HTTP GET request on the current page URL with the `ask` query parameter, and the optional `goal` query parameter:
```
GET https://vci-gci-docs.clinicalgenome.org/vci-gci-docs/gci-help/evidence-collection-experimental-evidence/rescue-evidence.md?ask=&goal=
```
`ask` is the immediate question: it should be specific, self-contained, and written in natural language.
`goal` is optional and describes the broader end goal you are ultimately trying to accomplish on behalf of the user. GitBook uses it to tailor the answer towards what is most useful for that goal.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.
Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.