VCI users can potentially publish an approved interpretation to two external repositories:
The ClinGen Evidence Repository (ERepo)
Available to fully approved ClinGen VCEPs
Process is API-driven (automated)
Available to users curating as part of any affiliation
Process is manual (data is downloaded to spreadsheet)
Option for both individual variant and batch submissions
Both publishing options are available via the Summary Page.
Note, these options are not available to users curating without an affiliation.
Fully approved ClinGen VCEPs can publish their approved interpretations to the ERepo via the summary page.
Click the Publish to Evidence Repository button to open the "Publish Interpretation to the Evidence Repository" box.
You will be asked to select a reason, or reasons, for publishing the curation. This information will be used by the ERepo to designate the curation's version number.
If this is a new curation, please select "New Curation". This disables the other checkboxes as they are only applicable to previously published curations.
If this is a recuration, or you are publishing with a minor (administrative) update please select all relevant reasons.
Click the Preview Publish button to see a preview of the interpretation to be published.
Click the Publish button, and the data will automatically be published to the ERepo.
The summary page will update to reflect the published status, and the option to Unpublish from the ERepo will be available.
Roll your cursor over the for details about each reason.
VCI users curating as part of any affiliation can use the "ClinVar Submission" buttons on their approved interpretation snapshot to generate data that can be submitted to ClinVar via spreadsheet.
The Batch Submission option was introduced in November 2022.
Batch submission does not auto-submit variants to ClinVar from the VCI. It is used to generate a ClinVar submission file which must then be downloaded and submitted to ClinVar.
Click on Add to Current Batch to add a variant to a batch
Note, if this is the first variant added, a new batch will be created and named with current month and year
The "Add" button 
will change to a "Remove" button 
The batch name will be added to the Publishing Status for the variant.
Click on the Batch name to view the current and closed ClinVar Submission Batches for the Affiliation.
Once all desired variants have been added to the batch, click Generate Submission Data, which opens the ClinVar Submission Data window.
Click Generate. Once the data populates, click Copy (to clipboard).
The data can now be pasted into a spreadsheet and submitted in the ClinVar submission portal.
Once the data has been submitted to ClinVar, click the Edit button to open the Edit Current Batch window.
Change the Status from "In Progress" to "Submitted to ClinVar." The Date Submitted field will now be available to edit and a Warning will appear.
You must type "Confirm" into the text box to proceed. Then click the Save button to close the batch.
The submission batch will now be listed under Closed Batches on the affiliation's ClinVar Submission Batches page.
The Publishing Status of all variants in the batch will be updated to "Closed Batches."
