When curation of a record is complete and ready for review by the expert panel, it can be moved to Provisional status.
Below the saved Summary Classification panel (see previous step), a new option enables you to save the curation and Summary Classification as a Provisional record. You can enter the date the curation was reviewed by you prior to saving, and add any additional comments in a free-text field.
If you move away from the Summary Classification page before previewing and saving the classification as a Provisional record, you have to re-save the Summary Classification (no changes are needed) to get the option to save as a Provisional record.
When you are ready to save the gene-disease curation as Provisional, select the "Preview Provisional" button.
The preview will show the timestamp of the submission, which is equivalent to the time at which the Provisional Classification is saved. Select the "Submit Provisional" button when you are ready.
After submitting/saving a Provisional classification, a panel providing the option to approve the gene-disease record will appear (see following section). The panel below that summarizes the saved classifications for the gene-disease record. Selecting the "Provisional Summary" link will open a new page or tab that shows the current Evidence Summary for the saved classification.
The top panel of the Evidence Summary shows top-level information about the gene-disease record and is followed by a panel containing the free-text curation summary (also labeled "Evidence Summary").
This is followed by the Calculated Classification Matrix and Scored Evidence tables. As in the preview version (see the description here), the tables summarize the saved evidence, sorting it according to evidence types (Case Level, Case Level for segregation evidence when there is no associated proband, Case-Control, and Experimental). Evidence with a score status of “Score,” “Review,” or “Contradicts” is shown. Only those rows of evidence where the score status was set as “Score” are included in the calculation for the total points shown at the bottom of each evidence table.and a series of tables
Below the Curation Central header panel, the central panel will now show the Provisional classification. It also now gives you the option to "View/Approve Current Provisional".
Once a Provisional Classification is submitted, it can not be edited. It will remain viewable and can be saved as Approved if no further changes are needed. However, the curation interface will remain active -- new evidence can be added and existing evidence can be edited. Updated Summary Classifications can be saved and submitted as a new Provisional Classification. The prior Provisional Classification will then be archived.
